Background: Lymphomas are a diseases group caused by malignant lymphocytes which accumulate in lymph nodes and cause the clinical features of lymphadenopathy. The main subdivision of lymphomas is Hodgkin's lymphoma and Non-Hodgkin's lymphoma. Aim of the work: The aim of this study was to study the epidemiology of Non Hodgkin Lymphoma in Clinical Oncology and Nuclear Medicine Department in Zagazig University Hospitals. Patients and methods: This retrospective cross-sectional study was carried out in Clinical Oncology and Nuclear Medicine department of Zagazig University Hospitals. Approval for the study was obtained from research administration and the Research Ethics Committee, Faculty of Medicine, Zagazig University. Results: there was statistically significant difference between male and female regarding the cervical site of the tumor. Results: There was a high statistical significant difference between males and females as regard hemoglobin level. Also, there was a statistical significant difference between the age groups ≤ 50 years and > 50 years in regard to chemotherapy and target therapy, while there was no statistical significant difference between the age groups ≤ 50 years and > 50 years regarding to radiotherapy. Conclusion : There was of paucity of the incidence and mortality data on lymphomas in Sharqia governorate. NHL is an important reason for cancer mortality in Zagazig. The incidence of NHL in Egyptians are several-fold higher, indicating that the national cancer burden was raised with Zagazig's economic progress.