BACKGROUNDː Acute kidney injury (AKI) is a one of the commenest complication of cardiac surgery. Early detection of AKI is of great importance since the advance of AKI is a heavy burden both on patients and health system. Several biomarkers have been revealed to predict and diagnose AKI in recent years. Raised serum uric acid level was related to an increased possibility of acute kidney injury by several and interactive pathways contributing to the development of chronic kidney disease . The aim of the present study was to obtain the role of serum level of Uric Acid (SUA) preoperative in prediction of acute renal injury (AKI) in post cardiac surgery. METHODSː This is a prospective observational study of patients undergoing cardiac surgery. Blood samples for measurement of uric acid preoperatively and follow-up for AKI postoperatively. Patients were divided into two groups as AKI and non-AKI. RESULTSː Sixty five patients (44 Males, 21 females) were included. After cardiac surgery, 24 (36.92%) patients developed AKI and serum uric acid was significantly increased in AKI patients. A higher predictive ability of SUA for AKI (AUC; 0.74, P=0.016) is observed by using receiver operator characteristics (ROC) curve analysis CONCLUSIONSː Preoperative uric acid may be an independent risk factor for postoperative AKI after cardiac surgery and may significantly predict AKI.