ABSTRACT
Background: Polycystic Ovarian Syndrome (PCOS) is an endocrine disorder in infertile women. With about Infertility rate of 40% in PCOS women. Determination the infertility causes and choosing the appropriate treatment is a diagnostic and therapeutic priority. Aim and Objectives : The aim of this work was to compare the effect of Clomiphene citrate plus Estradiol Valerate versus Letrozole on endometrial thickness and pregnancy rate in infertile PCOS women underwent ovulation induction. Patients and methods: this is randomized clinical trial has been carried out in infertility clinic of cytogenetic and endoscopy unit, Gynecology and Obstetrics Department, Faculty of Medicine, Zagazig university, Egypt during the period from March 2019 to September 2019,carried on 70 infertile women with PCO and were divided to 2 two groups , 35 patients patient received clomiphene citrate plus estradiol valerate and 35 patient received letrozole. Results : the results showed that there was a statistical significant difference between the studied groups (P value ≤ 0.001) regarding endometrial thickness, which was higher in Letrozole group B ( 9.7 ± 1.1 ) than clomiphene plus estradiol group A ( 8.8 ± 1.2). Rate of pregnancy was higher in the Letrozole group B (45.2%) compared to clomiphene plus estradiol group A (22.9%). Conclusion: Letrozole increase the endometrial thickness and rate of pregnancy more than the Estradiol Valerate and Clomiphene citrate in the infertile PCOS women who had abnormal endometrial thickness with Clomiphene citrate, so it is recommended for infertile PCOS women.