Background: Hyperemesis gravidarum (HG) is characterized by intractable nausea and vomiting, dehydration, large ketonuria, and loss of more than 5% of pre-pregnancy weight. HG adversely affect maternal wellbeing‚ significantly leads to physical, psychological, social consequences and hospitalization. The psychological component of HG remains unclear; and the relationship between HG and psychological problems such as depression is not completely understood. Aim: To assess the relationship between HG and psychological problems mainly depression; and to assess its presence and severity in pregnant women with and without HG. Methods: A case-control study on 26 cases of pregnant women hospitalized with the diagnosis of HG and 26 pregnant women with nausea and vomiting of pregnancy were evaluated as the control group. All patients in the study completed the 24-hour Pregnancy Unique Quantification of Emesis and Nausea (PUQE) ‚ Beck depression inventory (BDI). Results: There was a high statistical significant difference between HG cases and controls regarding frequency of emesis ‚retching and self-evaluation of well-being. Mean of BDI was 30.69±5.4 in HG cases while it was 16.69 ±6.62 in control group (p ˂0.05) with high statistical significant difference. Conclusion: Depression was more common and severe in cases with HG compared with controls.