Background: Stem cell therapy is considered as a golden type of therapy that can help us in the future to solve many problems that we suffer from them. We can use stem cell in treating many communication disorders as in autism and in vocal fold regeneration after atrophy and scar. Subjects and methods: We collected studies done on using stem cell in autism and vocal fold regeneration in the last 15 years in from 1-2002 until 3-2017 in Pub-med and e-medicine Results: We extracted the information from the studies and the results were discussed to know stem cell effectiveness and safety. Conclusion: Stem cell therapy is effective in treating many symptoms of autism and improve histology and morphology of vocal fold after atrophy and scar of vocal fold also, stem cell therapy is safe.