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55157

C-reactive protein in patients with major depressive disorder in Zagazig university hospitals.

Article

Last updated: 01 Jan 2025

Subjects

-

Tags

Psychiatry

Abstract

Abstract

Background: The relationship between inflammation and psychiatric disorders has been widely debated. Psychiatric patients had features of inflammation, such as high levels of inflammatory markers. This study was conducted to assess plasma C-reactive protein level (CRP) in patients with major depressive disorder (MDD) and compare them with healthy controls.


Methods: A sample of 196 participants (98 cases, 98 controls) was taken, cases satisfied the diagnosis of MDD according to Diagnostic and statistical manual of mental disorder (DSM-5). Blood samples were collected from patients and controls to measure plasma levels of CRP. Severity of depression in patients was assessed by Beck depression inventory and the Hamilton depression rating scale.

Results: There was a statistically significant elevation of CRP levels in patients with MDD compared to control group with P value 0.009. Also there was a significant correlation between CRP level and degree of severity of depression.

Conclusion: CRP was elevated in patients with MDD and associated with severity of MDD. This result supports the previous findings that inflammatory hypothesis has a great role in major depressive disorder pathogenesis.

DOI

10.21608/zumj.2019.16998.1523

Keywords

Keywords: Major depressive disorder, Inflammation, C-reactive protein

Authors

First Name

alaa

Last Name

ashraf

MiddleName

-

Affiliation

psychiatry department, faculty of medicine, Zagazig university, Sharkia, Egypt.

Email

alaaashraf157@hotmail.com

City

-

Orcid

-

First Name

Rafik

Last Name

Abd El-Latif

MiddleName

Reda

Affiliation

psychiatry department, faculty of medicine, Zagazig university, Sharkia, Egypt

Email

rafikrdabdlatif@yahoo.com

City

-

Orcid

-

First Name

Amany

Last Name

El-Shabrawy

MiddleName

-

Affiliation

Assoc. Prof. of Psychiatry, Zagazig University

Email

ahmed2001go@yahoo.com

City

-

Orcid

-

First Name

Abdallah

Last Name

Ibrahim

MiddleName

Saad

Affiliation

psychiatry department, faculty of medicine, Zagazig university, Sharkia, Egypt

Email

asaad1983@yahoo.com

City

-

Orcid

-

Volume

27

Article Issue

3

Related Issue

24506

Issue Date

2021-05-01

Receive Date

2019-09-16

Publish Date

2021-05-01

Page Start

501

Page End

510

Print ISSN

1110-1431

Online ISSN

2357-0717

Link

https://zumj.journals.ekb.eg/article_55157.html

Detail API

https://zumj.journals.ekb.eg/service?article_code=55157

Order

276

Type

Original Article

Type Code

273

Publication Type

Journal

Publication Title

Zagazig University Medical Journal

Publication Link

https://zumj.journals.ekb.eg/

MainTitle

C-reactive protein in patients with major depressive disorder in Zagazig university hospitals.

Details

Type

Article

Created At

22 Jan 2023