Background: Malignant pleural effusion (MPE) is determined by the detection of malignant cells in pleural fluid or pleural tissue. Neoplasm of lung, breast, ovary, and lymphoma are the causes of more than 75% of MPE. Pleurodesis is a usual technique in the management of MPE to achieve a symphysis between two layers of the pleura, and various chemical agents have been used in an attempt to produce pleurodesis.
Aim and objectives: The aim of this study is to evaluate the safety, efficacy and the success rate of 10% povidone-iodine in pleurodesis procedure through thoracostomy by conducting the objectives which were assessment of radiological outcome after using of povidone –iodine as a chemical pleurodesis , assessment the clinical outcome after using of povidone –iodine as a chemical pleurodesis and evaluation the effect of povidone-iodine on thyroid function test.
patients and methods: this is randomized clinical trial , was carried out on 24 cases at Cardiothoracic Surgery Department, Zagazig and Tripoli University Hospitals, all patients, who underwent pleural drainage and received bedside pleurodesis with 10% povidone-iodine, The efficacy of pleurodesis was defined in three levels of response
Results: the results revealed that Early response was 70.8% complete, partial in 25%, and failure 4.2%, major complication was nausea, regard follow up successes (complete and partial) 87.5% and failure 12.5%.
Conclusions: Povidone-iodine is a safe and effective agent with minor side effects in pleurodesis and treatment of MPE and proposed povidone-iodine as a proper, accessible, and low-cost alternative sclerosing agent.