Background: Coronary artery disease (CAD) is the most common cause of mortality worldwide and determination of contributing factors is essential. Studies have demonstrated the association of severe anatomical coronary artery disease (CAD) with postprandial triglycerides (TG) concentrations. Nevertheless the relationship between less severe atherosclerosis plaque burden and postprandial TG is less established. Objective: The study was aimed to study the significance of postprandial triglyceride as predictor for the severity of coronary artery disease. Patients and methods: The current study included one hundred and five individuals presented to Cardiology Department, Zagazig University Hospitals, within a time period of six months from July 2018 to December 2018, Inclusion criteria includes CAD based on coronary angiography. Results: In our study, ischemic heart disease is statistically higher in patients with abnormal CA and abnormal postprandial TG versus patients of abnormal CA with normal PP TG (51.9% versus 28.6%) respectively. Conclusions: According to our results, we concluded that a high level of postprandial TG would be a more reliable test than fasting TG in predicting the severity of CHD.