Background Despite existence of different therapeutic modalities, treatment of warts especially recalcitrant one remains a continuing challenge as there is no treatment modality exhibited high efficiency and low recurrence rate. Recently, intralesional immunotherapy via different types of antigens has proved high efficacy in the treatment of different types of warts.
Objective To evaluate the efficacy and safety of intralesional Candida antigen in treatment of recalcitrant warts.
Methods The study included 24 patients with recalcitrant warts. All patients were injected with 0.2 ml of 1/1000 solution of C. albicans antigen at 2-week intervals until complete clearance or for a maximum of six treatment sessions. Follow-up was done every month for six months to detect any recurrence.
Results 14 patients (58.3%) showed complete response, 6 patients (25%) showed partial response and 4 patients (16.7%) showed no response with no change in warts size throughout treatment sessions. Adverse effects were insignificant and no recurrence of warts was detected.
Conclusion Intralesional Candida antigen immunotherapy is a safe, promising and effective treatment modality for recalcitrant warts.