Background: Coronary artery disease (CAD) is a major cause of morbidity and mortality over the world. The atherosclerosis can developed through many years and symptoms occur, generally in middle age. The risk of developing CAD increases with age including age >45 years in men and >55 years in women. Objectives: The presented study was aimed to evaluate the dynamic changes of systolic and diastolic blood pressure in hypertensive patients with ischemic heart disease pre and post percutaneous coronary intervention (PCI), and to determine the effects of PCI on the elevated blood pressure on the CAD patients. Patients & Methods: Our study had been carried out in cardiology department, Zagazig University from October 2017 to September 2018. This study included 100 patients with hypertension and coronary artery disease. The patients were subjected for complete history taking, clinical examination, elective PCI and ambulatory blood pressure monitoring before and one month after PCI. Results: Results showed a highly significant difference between the ambulatory blood pressure pre and after coronary intervention, a significant decrease in the mean values of SBP and DBP (140/84 mm Hg) and the percentage of changes in BP after PCI revealed more decrease at night in the mean values of SBP and DBP compared with percentage at day. Conclusions: PCI is efficiently control and improve the blood pressure among hypertensive patients with CAD.