Abstract
Background: The aim of this study was to investigate the role of presepsin in evaluation of severity and outcome of community –acquired pneumonia in pediatric department of Zagazig University hospitals.
Methods: A prospective case control study was carried out at the pediatric Department of Zagazig University Children Hospitals during the period from February 2017 to October 2017.
Results: there was statistically significant difference between case and control groups in Preserpin level, there is statistically significant difference in presepsin level between cases that need Icu dmission and M.V. and cases treated in ward only without need for Icu admission and M.V, therewas statistically significant difference in presepsin level between survivors and non-survivors. In this study, there was statistically significant difference in presepin level with disease severity.in which presepsin is higher in severe than moderate and mild cases. we tried to detect the cutoff point of presepsin to detect the community acquired pneumonia calculated from ROC curves it was > 0.8 (ng/ml), and the area under the curve of presepsin was 0.833 with senstivity 97.8% and specificity 72%.
Conclusion Presepsin is a useful diagnostic and prognostic marker for pneumonia in Pediatrics. The present study suggests that Presepsin is a promising biomarker for reflecting the severity of Community- Acquired Pneumonia. Presepsin in combination with PRESS score may improve the predictive accuracy for severity and outcome of community acquired pneumonia in pediatrics.
Corresponding author:
Name: Mohamed Zaki Abdallah, Tel:01016532687, Email:mzakimzaki231@gmail.com