Acne vulgaris in adult women is a chronic inflammatory disorder of pilosebaceous unit with many relapse cases. It commonly has psychological and social impact that interfere with the quality of life of many patients. Androgenic hormones have a very important role in the pathogenesis of acne. Androgens affect many functions in our body therefore, any alternation in androgen receptors may have an important implication in the development of the signs of hyperandrogenic states in women. The early diagnosis of these hyperandrogenic states is a very important point for the proper evaluation of the patient of acne and for the better choice of therapeutic management. Defining a pattern for laboratory profile analysis is very useful in the control of relapse cases of acne vulgaris in adult women. Which lately has been the aim of many of published studied.
Aim to establish the relation between 3 alpha-diol G levels and acne in female patients with normal androgenic status without menstrual dysfunctions in comparison with controls, in an attempt to elucidate its role in the pathogenesis of acne vulgaris which might help in treatment.