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31529

Evaluation of primary immunodeficiency in patients with meningitis in fever hospitals

Article

Last updated: 01 Jan 2025

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Abstract

Background: The hallmark of primary immunodeficiency diseases is increased susceptibility to recurrent, severe and opportunistic infections. In this study we evaluate patients with meningitis for underlying primary immunodeficiencies.

Methods: During the period from August 2016 to February 2017, thirty infant and children patients (16 male and 14 female) with age ranged from 40 days to 15 years participated in the study were admitted to Faqus and Zagazig fever hospitals with meningitis were evaluated for primary immunodeficiencies by measurement of serum immunoglobulin levels, assessment of T-Cell Receptor Excision Circles and assessment of complement system by CH50 assay.

Results: This study showed that (50%) had deficient IgG, (20%) had deficient IgA, (30%) hyper IgE, (30%) hyper IgM and 10% Deficient in all Immunoglobulins. The study also showed that (43.3%) of the study group had TREC deficiency, (36.7%) were CH50 deficient and 26.7 had both TREC and CH50 deficiency.

Conclusions: Meningitis may be the presenting manifestation of immunodeficiency diseases as there is high incidence of primary immune deficiency in patients with meningitis. TRECS and CH50 are decreased in most cases of meningitis which indicate high percentage of primary immunodeficiency diseases among those patients.

DOI

10.21608/zumj.2019.11144.1155

Keywords

Meningitis, primary immunodeficiency, CH50, TREC

Authors

First Name

Marwa

Last Name

Eldarawy

MiddleName

Elsayed

Affiliation

Pediatric department, Faculty of Medicine, Zagazig University, pediatric department, faqus general hospital Sharkia, Egypt.

Email

meroeldarawy@gmail.com

City

Faqus

Orcid

-

First Name

mervat

Last Name

hesham

MiddleName

-

Affiliation

pediatric department, faculity of medicine, Zagazig university

Email

m_hesham592000@yahoo.com

City

-

Orcid

099776655460009

First Name

mohamed

Last Name

almalky

MiddleName

Abdelkader

Affiliation

Pediatric Department, Faculty of Medicine, Zagazig University, egypt

Email

drmohamedalmalkyped@yahoo.com

City

zagazig

Orcid

-

First Name

Ahmed

Last Name

Fakhr

MiddleName

Elsadek

Affiliation

Microbiology and Immunology Department, Faculty of Medicine, Zagazig University, Egypt

Email

ahmed_fakhr@yahoo.com

City

Zagazig

Orcid

0000-0002-0497-4908

Volume

26

Article Issue

1

Related Issue

8976

Issue Date

2020-01-01

Receive Date

2019-04-07

Publish Date

2020-01-01

Page Start

17

Page End

27

Print ISSN

1110-1431

Online ISSN

2357-0717

Link

https://zumj.journals.ekb.eg/article_31529.html

Detail API

https://zumj.journals.ekb.eg/service?article_code=31529

Order

3

Type

Original Article

Type Code

273

Publication Type

Journal

Publication Title

Zagazig University Medical Journal

Publication Link

https://zumj.journals.ekb.eg/

MainTitle

Evaluation of primary immunodeficiency in patients with meningitis in fever hospitals

Details

Type

Article

Created At

22 Jan 2023