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31343

Correlation between Uric Acid, Albuminuria and Cardiovascular Outcome In Patients With Diabetes Mellitus

Article

Last updated: 01 Jan 2025

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Tags

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Abstract

Background: Many studies have shown an association between uric acid (UA) and cardiovascular (CV) outcome in general population and diabetes, also the association between albuminuria and cardiovascular outcome is well established. The link between serum UA levels and albuminuria with subsequent CV affection is not yet clear. For this reason, we aimed to study such association. Method: One hundred and eight individuals with type 2 diabetes which were divided into two groups each constitute of 54 individuals according to presence or absence of CV disease. Routine laboratory investigations together with serum UA and urinary albumin to creatinine ratio (uACR) was analyzed in the two groups they were then correlated to each other and to different study parameters and future CV event using Framingham risk score (FRS). Results: The present study proved that there is statistical significant difference as regard risk of CVD as calculated by FRS being higher in diabetic patients with high serum UA (SUA) levels compared to those with low uric acid levels; the same apply for those with high urinary ACR. Serum UA was found to be correlated with urinary albumin execretion in patients with diabetes with and without CVD (n=108, r=0.450, p

DOI

10.21608/zumj.2019.12142.1212

Keywords

Uric acid, albuminuria, Diabetes mellitus, cardiovascular outcome, Framingham risk score

Authors

First Name

Usama

Last Name

Ragab

MiddleName

-

Affiliation

Internal Medicine Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt

Email

usama.ragab.zu@gmail.com

City

Zagazig

Orcid

0000-0001-5411-1943

First Name

Fayrouz

Last Name

Selim

MiddleName

Othman

Affiliation

Internal Medicine Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt

Email

feroo02012@hotmail.com

City

-

Orcid

-

First Name

Ahmad

Last Name

Elagrody

MiddleName

Ibrahim

Affiliation

Internal Medicine Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt

Email

agrody666@yahoo.com

City

-

Orcid

-

First Name

Mohamed

Last Name

Mourad

MiddleName

Hossam Elidn

Affiliation

Clinical Pathology Department, Faculty of Medicine, Zagazig University, Zagagzig, Egypt

Email

m_hosameldin@yahoo.com

City

-

Orcid

-

First Name

Mohamed

Last Name

Sakr

MiddleName

Mohamed

Affiliation

Internal Medicine Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt

Email

msakr461@gmail.com

City

-

Orcid

-

Volume

26

Article Issue

1

Related Issue

8976

Issue Date

2020-01-01

Receive Date

2019-04-26

Publish Date

2020-01-01

Page Start

7

Page End

16

Print ISSN

1110-1431

Online ISSN

2357-0717

Link

https://zumj.journals.ekb.eg/article_31343.html

Detail API

https://zumj.journals.ekb.eg/service?article_code=31343

Order

2

Type

Original Article

Type Code

273

Publication Type

Journal

Publication Title

Zagazig University Medical Journal

Publication Link

https://zumj.journals.ekb.eg/

MainTitle

Correlation between Uric Acid, Albuminuria and Cardiovascular Outcome In Patients With Diabetes Mellitus

Details

Type

Article

Created At

22 Jan 2023