Background: T2DM is a major risk factor for heart failure, peripheral arterial insufficiency and microvascular complications, affecting life quality and expectancy. Diabetes also increases coronary death rates conferring the patient a worst prognosis after having the first CHD event. The mortality rate in non-diabetic patients was less compared to diabetic patients who experienced CHD. Objectives: to study was the association of nontraditional risk factors with incidence of coronary heart disease in Patient with Type 2 Diabetes. Patients & Methods: Our study had been carried out in cardiology department, Zagazig University from April 2017 to December 2017. The study included 105 patients divided into 3 groups; they were young and middle aged subjects selected conveniently according to specified groups (normal control group, diabetic control group without history of coronary artery disease and ischemic heart disease group with history of coronary artery disease. History and physical examinations were recorded and laboratory tests were performed for all patients. Results: showed that there ws a statistical significant difference regarding Diastolic dysfunction, Ventricular hypertrophy, Uric acid, Serum hsCRP, Serum fibrinogen and Homocystein in T2DM patients group. Conclusions: Cardiovascular risk factors were higher in subjects with diabetes compared to subjects without diabetes, Non-traditional cardiovascular risk factors may be related independently to incident coronary heart disease in T2DM patients.