Background:  The fourth leading cause of death is type 2 Diabetes Mellitus (DM). Attention to the QOL of the patient is increasing today rather than the longevity of the patient. Therefore, to prevent aggravation of metabolic disorders, the quality of life of diabetic patients should be maintained. There is a growing awareness that patient QOL and satisfaction with treatment have been improved after good glycemic control. The aim of this study was to assess health related quality of life in patients with type 2 diabetes attending Zagazig University hospital plus associations between HRQOL scores and some variables playing role in scenario of DM were also studied. Methods:A cross sectional study included 100 type 2 diabetic patients, They were subdivided according to glycemic control into 2 groups and 50 non-diabetic participants as control. This study was conducted in Internal Medicine department and diabetes outpatient clinic in Zagazig University hospital in period from July 2016 to July 2018. The QOL was measured using SF-36 questionnaire. Results:  Our results revealed that there was highly significant difference regarding physical health component among groups of study (p <0.001). There was also highly significant difference regarding mental health component among groups of study (p <0.001). There was highly significant negative correlation between QOL components and age & BMI & duration of DM & HBA1c and fasting blood sugar in diabetic patients (p <0.001). Conclusions: Type 2 diabetes mellitus in both the physical health and mental health domains is associated with a lower quality of life. Advanced age, obesity and poor glycemic control were factors related to lower quality of life in this study; therefore glycemic control is highly needed to improve the quality of life of diabetic patients.