Background: Chronic plantar fasciitis is a common orthopedic condition that can demonstrate hard to effectively treat. In this study, platelet-rich plasma (PRP), a concentrated bioactive blood segment wealthy in cytokines and growth factors, was compared to cortisone injection in the treatment of Chronic plantar fasciitis resistant to traditional nonoperative management. Methods: Between October 2016 and the end of September 2017; sixty patients exhibited to New Cairo clinic with chronic plantar fasciitis, 30 patients were treated with PRP infusion, and 30 patients were treated with corticosteroid injection. This study compares the efficacy of (PRP) with that of corticosteroid local injection in chronic plantar fasciitis toward the finish of follow up time of 6 months concurring AOFAS score framework out of 100. Results: At the end of follow up, group treated by plasma rich platelets injection demonstrated that mean score was 83.5 of 100. While other treated by corticosteroid injection demonstrated mean score was 61.8 of 100 .No complication detected after the end of follow up period. Conclusions: Both PRP injection and corticosteroid injection are modalities for treatment of chronic plantar fasciitis. PRP preparation is a costly and complicated procedure than corticosteroid injection but PRP is more powerful and strong than cortisone injection for the treatment of chronic plantar fasciitis. Concerning corticosteroid side effects PRP infusion is safer in treatment of Chronic plantar fasciitis.