Introduction: ACLF is acute deterioration of preexisting chronic liver
disease usually related to a precipitating event characterized by the
presence of organ failure and a very high risk of short-term mortality. We
focused in this study on mortality outcome among ACLF patients which is
more devastating than patients with mere acute decompensation. Several
definitions have been developed by expert groups all over the world for
better characterization of this group of patients; however there is no
consensus on one definition. Aim of the study: to identify the
characteristics of patients with ACLF and their mortality in Zagazig
university hospitals. Patients and methods: we followed patients admitted to
hepatology intensive care unit with acute hepatic decompensation, we
included 30 patients of them as ACLF and they were managed with tight
monitoring and close follow up till either discharge or death. Results: The
present study proved that there was high mortality rate among ACLF
patients in our study (19 out of 30 patients). Conclusion: ACLF carries a
high mortality rate in comparison with patient's admitted with acute
decompensation.