Objectives: To describe the diagnostic performance of dynamic contrast enhanced MRI in differentiating between benign and malignant breast lesions. Methods: the study was conducted on 40 patients with 40 lesions. MR examinations were performed using a closed MRI machine with magnets of intensity field 1.5 Tesla system,equipped with bilateral dedicated breast coils. All lesions were biopsied considering histopathologic findings as the standard of reference. Probability of malignancy was assessed according to BI-RADS for DCE-MRI. Diagnostic accuracy of DCE-MRI was statistically analyzed. Results: Regarding to the final outcome of the reviewed 40 MRI studies depending on the histopathological results accepted as standard reference, histopathology revealed malignancy in 67.5 % of lesions (27/40) and DCE-MRI showed sensitivity (96.3%) and specificity (76.9%) Conclusions: Dynamic contrast enhanced MRI facilitates differentiating benign and malignant breast lesions.