Background: The significance of the contribution of laboratory medicine to clinical cardiology has grown in importance over the years. This is witnessed by the recent incorporations of biomarkers into new international guidelines and in the re-definition of myocardial infarction (MI). Aim of the work: The aim of this study is to evaluate the most important cardiac biomarker in risk evaluation in patients presenting by symptoms of cardiac ischemia. cTnT, HsCRP, pro-BNP and GDF-15 will be assayed to correlate their levels with known clinical and angiographic risk factors. Subjects & Methods: The study subjects included 80 adult subjects. They were divided into the following groups: Group (I) STEMI: 30 subjects, group (II) Non STEMI: 30 subjects and group (III) controls:20 healthy volunteers age and sex matched. Results: cTnT showed statistically significant difference between the three studied groups. As regard hsCRP and pro-BNP, there was a statistically significant difference between group (I&III) and group (II&III). As regard GDF-15, there was a non-statistically significant difference between the three studied groups. When both patient groups were compared regarding angiographic findings, patients of NSTEMI group showed higher percent of having multi-vessel disease than those of STEMI group. Conclusion: All studied biochemical markers except GDF-15 showed a statistically significant difference between cases and controls, while only troponin T showed a statistically significant difference between both patient groups.