Objective: to study the effect of antireflux therapy in the form of PPI and sodium alginate, on the voice outcome after phonomicrosurgery of vocal fold polyps. Study Design: All patients with vocal folds polyps were seen in the outpatient clinic and phoniatric unit of otorhinolaryngology department, Zagazig University Hospitals in the period from July 2016 to January 2018. Patients were divided into 2 groups one group received antireflux therapy in the form of proton pump inhibitors (omeprazole 20mg twice daily plus liquid alginate (gaviscon advance) one table spoonful 10ml 1×3after meal and at bed time. The duration of treatment was 8 weeks. The other group wasn't received antireflux therapy postoperative. Results: A total of 24 patients met inclusion criteria and divided into two groups. In the two groups of 12 patients each from our study there was a statistically significant improvement regarding laryngeal evaluation, grades of dysphonia, the acoustic and aerodynamic parameters i.e. jitter (p = 0.001), shimmer (p = 0.02) and maximum phonation time (p = 0.001) and AFF (p = 0.04) in the group in which proton pump inhibitor and gaviscon advance were taken postoperative (group A) while in group B there is no Statistically significant difference in Average fundamental frequency.AFF, Jitter, Shimmer (p value above 0.05), but there was statistically significant difference in HNR (p = 0.05) and Maximal phonation time(MPT) (p value 0.008). Conclusion: The intake of combination of proton pump   inhibitor and gaviscon advance liquid is beneficial if taken after phonomicrosurgery for vocal fold polyp to overcome the acidic and non acidic components of the reflux with statistically significant results