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DOPAMINE RECEPTOR D3R AND D4R MRNA LEVELS IN PERIPHERAL LYMPHOCYTES IN PATIENTS WITH SCHIZOPHRENIA AND ITS CORRELATION WITH SEVERITY OF ILLNESS

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Last updated: 01 Jan 2025

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Abstract

ABSTRACT
Objective: This study aimed to assess D3R and D4R mRNA levels in patients with schizophrenia.
Subjects: Thirty six schizophrenia patients; 24 males (66.7%) and 12 females (33.3%) and 36 healthy
individuals; 23 males (63.9%) and 13 females (36.1%) as control subjects.
Methods: All schizophrenia patients are thoroughly screened and diagnosed for schizophrenia using
DSM-IV diagnostic criteria for schizophrenia.
Results: The mean values of D3 and D4 receptors mRNAs level among both studied cases and controls
show a highly statistically significant difference (P <0.001) between both schizophrenia patients and
their controls regarding levels of D3 and D4 mediators. D3 receptor mRNAs level influenced by PANS
scale of schizophrenic patients, as level of D3 R increased in PBLs with decreased schizophrenia
severity, and the difference was statistically significant (P <0.001), while the difference in D4 R level
was not statistically significant (P >0.05).
Conclusion: This study reveals that the molecular biologically-determined dopamine receptors (DR3
and DR4 mRNA) of peripheral lymphocytes are reactive after taking antipsychotics, and that increased
expression of dopamine receptor in peripheral lymphocyte has possible clinical significance for
subgrouping of schizophrenia.

DOI

10.21608/zumj.2018.13003

Keywords

DR3: dopamine receptor 3, DR4: dopamine receptor 4, RT- PCR: real time polymerase chain reaction

Authors

First Name

Asaad

Last Name

Shalanda

MiddleName

A.

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Orcid

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First Name

Rafek

Last Name

Abd Ellatif

MiddleName

R.

Affiliation

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City

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Orcid

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First Name

Mohamed

Last Name

Negm

MiddleName

G.

Affiliation

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Email

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City

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Orcid

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First Name

Amal

Last Name

El Shal

MiddleName

S.

Affiliation

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Email

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City

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Orcid

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First Name

Heba

Last Name

Abdelsalam

MiddleName

Ahmed

Affiliation

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Volume

24

Article Issue

1

Related Issue

2472

Issue Date

2018-01-01

Receive Date

2018-09-09

Publish Date

2018-01-01

Page Start

55

Page End

65

Print ISSN

1110-1431

Online ISSN

2357-0717

Article File

ZUMJ_Volume 24_Issue 1_Pages 55-65.pdf

PDF . 700.0kB

Link

https://zumj.journals.ekb.eg/article_13003.html

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https://zumj.journals.ekb.eg/service?article_code=13003

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Type

Original Article

Type Code

273

Publication Type

Journal

Publication Title

Zagazig University Medical Journal

Publication Link

https://zumj.journals.ekb.eg/

MainTitle

DOPAMINE RECEPTOR D3R AND D4R MRNA LEVELS IN PERIPHERAL LYMPHOCYTES IN PATIENTS WITH SCHIZOPHRENIA AND ITS CORRELATION WITH SEVERITY OF ILLNESS

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Article

Created At

22 Jan 2023