Background: This experimental study evaluated the effectiveness and safety of using cyanoacrylate tissue adhesive for reinforcement of intestinal anastomosis and as a protective seal to prevent leakage.
Methods: Twenty healthy adult model rabbits weighting 2000 ± 100 gm were included in this study. They were divided into two groups. Group I ( experimental group ) underwent intestinal resection anastomosis with one interrupted vicryl layer sutures , and N- butyl -2- cyanoacrylate as a tissue adhesive for reinforcement of anastomosis, while in group II ( control group ) the anastomosis was performed with one interrupted vicryl layer without cyanoacrylate . After 15 days the ileum was gently removed and assessed for wound infection, anastomotic leakage, adhesions, and for anastomotic stricture. The assessment also included pathological evaluation for inflammatory cell infiltration and collagen deposition.
Results: There was no statistically significant difference in anastomotic leakage, adhesions and anastomotic stricture. There was significantly lower inflammatory reaction and collagen deposition in the experimental group (I) when compared with the control group (II).
Conclusion: In this study we confirmed the effectiveness of N – butyl -2- cyanoacrylate for reinforcement of intestinal anastomosis, as an immediate sealing of the tissues and as support to the physiological wound healing process.