Background: Obesity and overweight are growing global epidemic,Resulting in significant morbidity and mortality and reduce quality of life Managing one's weight is one factor in preventing chronic diseases Aim & Objectives: Assessment of some approaches for weight reduction to decrease the prevalence of obesity to avoid its inherent hazards ,through the following objectives1-To assess overweight and local obesity .2- To educate participants about healthy lifestyle(dietary habits).3-To apply diet restriction ,acupuncture and mesotherapy Courses . 4-to assess the effect of the previous approaches in preventing obesity. Subjects & Methods: An interventional study was conducted in obesity clinics at Zagazig University Hospital during the academic year between 2011 and 2012.This study designed to compare the weight reduction effects of 3 approaches (mesotherapy, acupuncture and diet restriction) versus control for 460 adult women with body mass index BMI <35, treated for 8 successive weeks and obesity indexes including body weight, BMI and waist/hip ratio(WHR) were evaluated. Versus baseline, The study was carried out through 3 phases Results:. the obesity indexes decreased at the end of each treatment course (diet and acupuncture)(p < 0.05), while no decrease at BMI at the end of the mesotherapy course(p>0.05) with significant reduction at WHR (p<0.01). Conclusion: This study revealed that, that acupuncture then dietary caloric restriction reduced body weight while mesotherapy are effective body contouring approaches