Objective:In this study, the main objective was to determine prescription errors in family health units in Zagazig city accredited versus non accredited and its relation to the organizational climate. Patients &Method:10 accredited family health units were included in the study. Comparing the prescription of these unit to the standard of the ministry of health and WHO. Results:. It was found that the frequency of errors in accredited unit were fewer. The accreditation affects both the frequency of errors and the organizational climate, as the accredited units showed fewer errors and higher organizational climate score than the non-accredited units. There was a negative correlation between the organizational climate and the frequency of missing errors. Conclusions: Prescribers could be helped by designing systems to reduce the risk of these errors like that of a continuous education training programs and use of computerized prescription. The prescriptions need more effort and support from all the related to it; from the doctors, senior managers to the accreditation committee and ministry of health.