Abstract The skin is the largest organ of the body, accounting for about 15% of total adult body weight, it performs vital func-tions, including protection, against external, physical, chemical, biologic assailants through integumentary system composed of three layers, the epidermis, dermis, and subcutaneous tissue. The aim of this article is to highlight some important interactions with the skin, these interactions have great im-portant signs and diagnosed for many pathophysiology and skin diseases. Association between light, overweight, and neuropeptide and dermatologic conditions related to skin managements to these parameters will be impacted in this article.