Abstract Background: Sensitivity of colonoscopy in detecting pre-cancerous lesions depends on quality bowel preparation that is often negatively affected by low tolerability of patients to the different preparation protocols. Aim of Study: To evaluate the efficacy and tolerability of a novel solution (NUTRIMOV) combining PEG and a carbo-hydrate-electrolyte solution for colonoscopy. Patients and Methods: Fifty patients undergoing colorectal cancer (CRC) screening via colonoscopy. Split-dose of 4 L of NUTRIMOV were administered over a span of three days leading up to the colonoscopy. Results: Fifty patients (26 males, mean age 55±8 years) were included in the final analysis. Excellent and good bowel preparation was achieved in 72% of patients. Patient's tolera-bility was reported as good in 43%, moderate in 42% and poor in 15%. Adverse effects were hunger (22%), fatigue (36%), abdominal pain (4%), bloating (24%), but no vomiting (0%). Conclusion: NUTRIMOV is well tolerated by patients with low rates of adverse effects and results in high rates of adequate cleansing level.