Abstract Background: Breast cancer (BC) is the most commonly diagnosed cancer in women. It is also the leading cause of cancer death in women and occurs most frequently in post-menopausal women over the age of 50. Aim of Study: To evaluate the quality of life (QOL) in breast cancer patients after mastectomy. Material and Methods: Two hundred adult females with breast cancer and had mastectomy were participated in this study, selected from polyclinics. Quality of life was evaluated by using the Arabic version of EORTC QLQ-C30 and EORTC-BR23 questionnaires. Design of the Study: The study was designed as an obser-vational cross-sectional studyThe research related to human use has been complied with all the relevant national regulations and institutional policies, has followed the tenets of the Declaration of Helsinki, and has been approved by the Research Ethics Committee of the Faculty of Physical Therapy, Cairo University (No: P.T.REC/012/002856). Results: In the QLQ-C30, the highest functional score was for 'role functioning' and the lowest one was for cognitive functioning. In symptom scale insomnia and pain were the highest symptoms. The lowest symptoms were nausea and vomiting. While in the QLQ-BR23, the highest functional score was for sexual functioning and the lowest one was for future perceptive score. The highest symptoms score was measured for upset by hair loss and the lowest symptom score was for systemic therapy side effects. Overall health percentage score equal 57.35 which is low by referring to the reference value manual of EROTIC QLO-C30. Conclusion: Egyptian breast cancer survivors reported lower overall global QOL. Breast cancer affects all the domains of the quality of life.