Abstract Background: Musculoskeletal disorders are one of the most common complications in diabetic patients. The most common complaints are shoulder pain and limitation of movement. Aim of Study: The aim of this study is to evaluate the diagnostic performance of high-resolution ultrasound in the diagnosis of shoulder joint pain in diabetic patients. Material and Methods: This study was performed on 48 adult type 2 diabetic patients who were complaining of shoulder pain and/or limitation of shoulder movement. Greyscale sonography was done, comparing the results with fifty control subjects. Results: Supraspinatus tendon thickness (SST) was sig-nificantly greater in diabetics than in controls (p<0.001). There was no significant correlation between shoulder pain, clinical limitation of movement of the shoulder joint, and ultrasound findings in the diabetic group (p-value >0.05). However, there were significant SST tears, subacromial bursitis, and limitation of movement of SST ultrasound findings in older diabetic patients than in younger ones with a p-value (<0.05). In the diabetic patients, ultrasound revealed a sensi-tivity of 82.6% in detecting the underlying cause of shoulder pain. Also, it showed a 67.4% sensitivity and 50% specificity in the detection of the underlying cause of shoulder limitation of movement. Conclusion: Ultrasound may be a high-quality diagnostic tool for diabetes individuals with shoulder joint disorders.