Abstract Background: Inflammation has been shown to play an important role in the mechanisms involved in the pathogenesis of hypertension. Aim of Study: To evaluate the effect of circuit weight training on tumor necrosis factor-alpha on essential hyperten-sive patients. Material and Methods: Fifty hypertensive men patients participated in this study, their ages ranged from 40 to 50 years old, They were randomly assigned into two groups: Group A (study group) were 30 patients who participated in circuit weight training program performing 3 times per week for 8 weeks in addition to their medical treatment. Group B (control group) were 20 patients who received their medical treatment only. Results: Systolic blood pressure decreased by 6.46% in study group while was 1.15% in control group. Diastolic blood pressure decreased by 5.39% in study group while was 0.6% in control group. The tumor necrosis factor alpha de-creased by 28.21% in study group while was 1.76% in control group. Heart rate decreased by 5.18% in study group while was 0.43% in control group. Rate pressure product decreased by 10.49% in study group while was 0.76% in control group. Conclusion: Circuit weight training had great effect in decreasing tumor necrosis factor alpha, blood pressure, heart rate and rate pressure product.