Abstract Background: Much ammonia is produced by helicobacter pylori and by its eradication, the grade of hepatic encephalop-athy could be improved. Aim of Study: To evaluate the effect of H. pylori eradication on the stage of hepatic encephalopathy. Patients and Methods: This study included 80 cirrhotic patients infected with H. pylori which was diagnosed by stool antigen. The studied patients were further subdivided into groups according to the regimen of H. pylori eradication. Follow-up was done after one month to assess the effect of its eradication on the improvement of hepatic encephalopathy. Results: Follow-up after one month of treatment revealed that the eradication rate for H. pylori showed higher efficacy with Levofloxacin based therapy (89.47%) compared to Clarythromycin regimen (76.47%) with p-value=0.3. Most of cirrhotic patients with hepatic encephalopathy improved after successful eradication however without a statistical significance. Conclusions: Our results showed that H pylori eradication may improve the grade of hepatic encephalopathy.