Abstract Background: Transient elastography (TE) is a reliable tool for the non-invasive assessment of liver fibrosis in routine clinical practice. The widespread adoption of this technology is certain to increase the use of TE worldwide. Although TE has been well validated in chronic viral hepatitis, its clinical role in other liver diseases remains less clear. Aim of Study: To assess the role of transient elastography (fibroscan) in diagnosis and staging of liver fibrosis in chronic liver diseases among paediatrics in comparison to liver biopsy, Subjects and Methods: This is cross sectional study, was carried out on Children with chronic liver disease undergoing biopsy in Ain Shams University Hospitals during a period of 6 months. Result: Fibroscan and biopsy showed high substantial agreement regarding fibrosis stage (fibrosis or no fibrosis) with kappa (x) 0.667. Conclusion: Noninvasive methods, such as transient elastography and fibrosis marker scores, seem to be useful tools to assess liver fibrosis in these patients and may be helpful to recognize a progression of the liver disease during routine follow-up. TE is a portable, highly accessible, reliable, and reproducible noninvasive modality that can be used to screen for liver disease and assess severity of fibrosis in children with CF.