Abstract Background: Various surgical methods were described for treatment of lumbar disc prolapse including microdiscec-tomy, later sequestrectomy was described for preservation of disc height and minimalizing the surgical intervention. Aim of Study: The aim of this study is to evaluate the outcomes of lumbar disc fragmentectomy in patients with lumbar disc herniation in terms of pain (back pain and radic-ular) relief, improvement of neurological deficit if present, hospital stay duration, time consumed for return to work, and the incidence of complications with this intervention compared to conventional microdiscectomy. Patients and Methods: This is case series study, where patients having lumbar disc herniation were evaluated preop-eratively both clinically and radiologically patients were operated by microfragmentectomy and followed-up conducted for 3 months for recurrence rate and outcomes. Results: We operated twenty cases in this study, with microfragmentectomy, the mean age of patients was 34.75 years, there were 15 males and 5 females, postoperative pain improvement was better in microfragmentectomy. Hospital stay, blood loss, and postoperative complications were less in microfragmentectomy. Conclusion: Microfragmentectomy allows good surgical visualization and is less traumatic to the involved tissues. The results of this study indicated that microfragmentectomy reduces hospitalization time, improves the overall surgery related outcome, microfragmentectomy allows patients earlier return to work and normal life with less reliance on postoper-ative narcotic analgesic agents.