Abstract Background: Pre-term delivery is on of the main compli-cations of gestation accompanying with perinatal mortalities and morbidities. Implementation of approaches to avoid spontaneous pre-term delivery (s-PTB) is progressively stand-ardized, Progesterone and cervical cerclage utilized for the inhibition of pre-term labour. Aim of Study: To compare cervical cerclage and proges-terone for prevention of pre-term labour in females with history of pre-term labour. Subjects and Methods: This work is a randomized con-trolled trial, was carried at Obstetrics and Gynecology Dep. of El Hussein Hospitals of Al-Azhar Faculty of Medicine, on 400 females, from March 2020 till March 2021. Results: A significant change was found among the study groups according to 1ry outcome as regards Mean GA at delivery. Conclusion: The vaginal progesterone is successful as cervical cerclage in preventing pre-mature labour but its usage is better in clinical as it's noninvasive method and economic.