Abstract Background: Breast cancer is a major health problem globally, and the most common female cancer worldwide. Treatment of the disease is undergoing improvements and modifications continuously, and the recent two decades have witnessed major reforms in the management options. Aim of Study: In this study, we aimed to assess the effect of local glandular flap on seroma reduction. Patients and Methods: This prospective comparative study was conducted at tertiary care hospital at Ain Shams University Hospitals from March 2021 till December 2021 and performed on total 30 patients with breast cancer who underwent con-servative breast surgery. Results: Our study results revealed that Seroma was less frequent among flap group than among no flap group (30.0% versus 60.0%). The differences statistically were significant, while Hematoma were less frequent among flap group than among no flap group (0.0% versus 6.7%) with no statistically significant differences. The wound infection, dehiscence, fat necrosis and scar disfigurement were less frequent among flap group than among no flap group. The differences statistically were not significant (p=0.999). Regarding to cosmetic outcomes, our results revealed that cosmetic results (Nipple-areola shape and symmetry) were better among flap group than among no flap group (80.0% versus 60.0% and 73.3% versus 53.3%) respectively for good response. The differences statistically were not signif-icant (p=0.427 and 0.368) respectively. Conclusion: We concluded that there was statistically significant difference between the flap group than no flap group regarding the postoperative complications of seroma while hematoma, wound infection, dehiscence and fat necrosis or regarding cosmetic disfigurement of Nipple-areola, shape and symmetry of the breast with the contralateral side showed no significant differences between the flap group than no flap group.