Abstract Background: Preeclampsia is a multisystem disorder of pregnancy defined by the combination of new-onset hyperten-sion and proteinuria that contribute substantially to perinatal morbidity and mortality worldwide. Aim of Study: This study was sought to use Doppler ultrasound to assess the hemodynamic changes in the uterine, umbilical, and middle cerebral arteries, among pregnant women with and without Preeclampsia. Patients and Methods: A prospective Observational study of pregnant women who recruited from Department of Ob-stetrics and Gynecology, Aswan University Hospitals during September 2019 until March 2020, and may be extended if needed. Results: There is statistically significant difference between groups as regard to umbilical artery (RI and abnormality), middle cerebral artery (PI, RI and abnormality) and uterine artery (PI, RI, abnormality and notch) but there is no statisti-cally significant difference between groups as regard to umbilical artery PI (p-value=0.117). Conclusion: This study demonstrated that Doppler US can reveal the underlying hemodynamic repercussion in the maternal-fetal circulation and thus can be used to determine the proper level of antenatal care in pregnant women. Umbilical artery and Middle cerebral arteries indices were more altered in Preeclampsia.