Abstract Background: Caesarean delivery is the most common surgical procedure performed worldwide; but this procedure associated with severe postoperative pain, which prevent early ambulation, that in turn increase risk of respiratory complica-tions, venous thromboembolism, delaying breast feeding and prolong hospital stay. Aim of Study: To assess the efficacy off ultrasound guided Quadratus lumborum block versus ultrasound guided Trans-versus abdominis plane block in control of postoperative pain associated with caesarean section. Patients and Methods: After approval by the local ethical committee, a prospective, controlled, clinical, randomized study was carried out on 80 patients, and randomly allocated into two equal groups: Group A: Bilateral ultrasound guided posterior Quadratus lumborum block, and Group B: Bilateral ultrasound guided lateral Transversus abdominis plane block. An informed consent was taken from every patient subjected to this study. The Study Was Carried in The Period Between January 2021 Till September 2021 At Al-Azhar University Hospitals. Results: This study showed that no hemodynamics changes were found between both groups. Usage of posterior Quadratus lumborum block decreased postoperative pain and analgesic consumption in the first 24 hours after surgery along with longer pain free period compared to patients who were given lateral Transversus abdominis plane block. Conclusion: Usage of Ultrasound guided Quadratus lum-borum block provided effective modality for control of post-operative pain associated with caesarean section, as it provided long-lasting analgesia and reduces consumption of opioids than, Transversus abdominis plane block.