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225297

Histopathological Insights Into Sino-Nasal Mucormycosis in COVID-19 Patients and Related Pathogenesis

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Last updated: 22 Jan 2023

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Abstract

Abstract Background: Rhino-orbital-cerebral mucormycosis (ROCM) is an aggressive fatal fungal infection in COVID-19 patients with uncontrolled diabetes and corticosteroids therapy. Aim of Study: Early and accurate diagnosis of mucormy-cosis focusing on the pathognomonic histopathological features and related pathogenesis. Patients and Methods: This retrospective study included 28 nasal biopsies of COVID-19 patients, between the first of January and the end of August 2021, data was collected from one tertiary center. Demographic, serological, radiological and clinical data were obtained from reports. Histopathological evaluation of H&E stained sections, PAS and Masson trichrome stains were done for each paraffin block. Results: A spectrum of histopathological features was noticed; the pathognomonic ones are: mycotic abscess with multiple giant cells and Emperipolesis, mycotic bone necrosis and/or osteonecrosis, paucicellular fat necrosis and angioin-vasion. Mucorales and associated Splendore-Hoeppli phenom-enon were obvious in all examined sections. About 35% of patients were children (4-13 years) with pre existing or concomitant diabetes, all were positive COVID-19 (PCR and/or radiological findings). Conclusions: Early histopathological diagnosis and new therapeutic modalities are safeguards against the co- morbidity of mucormycosis in COVID-19 patients. Authors declare no conflict of interest.

DOI

10.21608/mjcu.2021.225297

Keywords

histopathology, mucormycosis, COVID-19

Authors

First Name

FATMA EL-ZAHRAA SALAH EL-DEEN YASSIN, M.D.

Last Name

FATMA MOHAMMED HAMDAN, M.D.

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Affiliation

The Department of Pathology, Faculty of Medicine, Sohag University

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Volume

89

Article Issue

December

Related Issue

22432

Issue Date

2021-12-01

Receive Date

2021-09-16

Publish Date

2021-12-01

Page Start

3,015

Page End

3,027

Print ISSN

0045-3803

Online ISSN

2536-9806

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https://mjcu.journals.ekb.eg/article_225297.html

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https://mjcu.journals.ekb.eg/service?article_code=225297

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94

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Journal

Publication Title

The Medical Journal of Cairo University

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https://mjcu.journals.ekb.eg/

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Article

Created At

22 Jan 2023