Abstract Background: Access to emergency contraception and its need for increasing awareness and convenience are very important nowadays. Post-coital or emergency contraception is a simple, reliable and effective strategy. However, the complications associated with the emergency contraception are needed to be addressed before its full potential is realized. Aim of Study: To compare between vaginal versus oral administration of levonorgestrel as a method of emergency contraception. Patients and Methods: This was a prospective randomized comparative study, was carried at Al-Hussein University Hospital during period from February 2021 till August 2021. Sixty women with regular cycle admitted to Birth Control Unit at Al-Hussein University Hospital divided into 2 groups: 1st Group: 30 women who received levonorgestrel 1.5 mg as a single dose orally (two tablet of Contraplan II) and 2nd Group: 30 women who received levonorgestrel 1.5mg as a single dose vaginally (two tablet of Contraplan II). Results: There was high statistically significant difference between the studied groups as regard platelets, BT, CT and PT. The pregnancy rate was less in vaginal group with no statistically significant difference between the two groups. There was statistically significant difference between the studied groups as regard nausea, abdominal pain, headache and vomiting. Conclusion: Among the Egyptian, the levonorgestrel-releasing intrauterine system (LNG-IUS) does not have any adverse effects on metabolic parameters, triglycerides (TGs), low-density lipoprotein (LDL) and blood sugar levels. Most of the studied patients were very or somewhat satisfied with methods and 30.43% were neutral or somewhat not satisfied the same result for recommend the method.