Abstract Background: Diabetes mellitus is a group of metabolic disorders in which there are high blood glucose levels over a prolonged period. Diabetes can cause many complications. Acute complications can include diabetic ketoacidosis, hyper-osmolar hyperglycemic state, Chronic complications include cardiovascular disease, stroke, chronic kidney disease, foot ulcers, and damage to the eyes. Aim of Study: To study the effect of cupping therapy on blood glucose level in type ll diabetic women. Material and Methods: Sixty type 2 diabetic patients were selected from out-patient clinic of Internal Medicine Depart-ment of Zagazig General Hospital. The practical work was done in the duration between July 2019 till February 2020. They were diagnosed with specialized physician as T2DM patients for more than 5 years, their age ranged from (55-65 years) and they were randomly assigned into two groups (A&B) equal in number. Each group consisted of thirty patients. Parameters measured from both groups were HbA1c and Pain. Group (A) performed aerobic training in the form of walking on treadmill with intensity ranged from 60-70% of HRmax only for three sessions every week for 3 months while group (B) performed aerobic exercise and cupping therapy once amonth for three months. Both groups were under medical treatment. Results: There was a significance decrease in HbA1c and pain in group B compared with group A post treatment. The percent of improvement of HbA1c and pain for group (B) was 14.76%, 45.05% and for group (A) was 10.36%, 37.88%, respectively. The significance decrease in the mean values post treatment (p=0.01), (0.01). Conclusion: Using cupping therapy combined with aerobic exercise is superior to aerobic exercises only regarding blood glucose level in type 2 diabetic women.