Abstract Background: Immunodeficiency is a major cause of illness, especially in people of Old age. Aim of Study: The study was conducted to evaluate the effect of exercise program on immunity system of male geriatrics with immunodeficiency disorder. Material and Methods: Forty male patients with immun-odeficiency disorders participated in the study, between 60 and 70 years old. They were divided randomly and equally into two groups: 20 patients group (A), in which patients received the regular medications plus the exercise program; and 20 patients in group (B), in which patients received just the regular medications. The exercise program contained aerobic, flexibility, strengthening and endurance exercises for 50-60min, three times per week, for 3 month assessment of patients in each group for immunty level (WBCs and lymphocytes), before and after treatment. Results: There was a significant increase in WBCs count, lymphocytes count and 6MWT post treatment in group (A) and group (B) compared with that pre treatment (p>0.001). The percent of increase in WBCs count, lymphocytes count and 6MWT in the study group was 147.45%, 293.83% and 40.68% respectively, and that for control group was 95.83%, 257.14% and 25.36% respectively. Conclusion: Exercises are effective in increasing immunity level in male patients with immunodeficiency disorders.