Abstract Background: The major prognostic factors in carcinoma of the bladder are the depth of invasion into the bladder wall and the degree of differentiation of the tumor. However, there is no reliable parameter predicting the risk of recurrence or progression. Molecular markers are, therefore, required to estimate the individual prognosis of patients as well as for effective treatment. Aim of Study: To evaluate HER2/Neu & CD 10 immuno-histochemical expression in urothelial carcinoma of the urinary bladder and to determine the correlation between immunohis-tochemical expression and histopathologic parameters includ-ing grade and stage, thus contributing as prognostic factors. Material and Methods: HER2/Neu and CD 10 were as-sessed by immunohistochemistry in 50 specimens of urinary bladder urothelial carcinoma, collected from Al-Azhar Faculty of Medicine Hospital labs during the period from January 2019 to February 2020. Specimens were obtained by either transurethral resection (TUR) or radical cystectomy. Results: There was a statistically significant difference in HER2/Neu and CD 10 expression in high grade urothelial carcinoma compared with low grade urothelial carcinoma, and in invasive urothelial carcinoma versus noninvasive urothelial carcinoma. Conclusion: HER2/Neu and CD 10 immunohistochemical expression was directly related to grade and stage of urothelial carcinoma of the bladder and could be of valuable significance in the differentiation between high and low-grade urothelial carcinoma of the bladder.