Abstract Background: Deep seated gliomas represent challenge to neurosurgeons as reaching these lesions may cause more harm than, application of neuronavigation lead to safe access and better results. Aim of Study: Presentation of our experience in resection of deep seated gliomas using intraoperative neuronavigation at our department. Patients and Methods: A prospective study including 31 cases with deep seated gliomas operated in our department in the period between January 2018 and December 2020. In all of these cases tumor was operated using intraoperative neuronavigation. This series included 18 males and 13 females. Results: In 8 cases the tumor was basal ganglia, in 10 cases the tumor was located in the frontal lobe, in 7 cases the tumor was located in the parital lobe and in 6 cases it was located in the temporal lobe. Motor deficit was present in 15 cases, aphasia in 5 cases, fits occurred in 3 cases. In cases with lobar gliomas the approach was different according to tumor location and more than 90% removal was obtained in 19 cases and more than 70% removal in 4 cases. In cases with basal ganglia lesions different biopsies was obtained from core and margins. The most common pathology was glioblas-toma in 21 cases. Conclusion: Intraoperative neuronavigation is very valu-able in resection of deep seated gliomas as it gives a chance to have multible biopsies from different locations in case of unoperable tumors, in operable cases it reduces morbidity by choosing a track that avoid eloquent brain areas in addition to proper flab localization.