Abstract Background: Organophosphates (OP) are one of the most common agents of poisoning in developing countries including Yemen. Where agriculture is a major component of the economy. Aim of Study: This study aimed to describe the prevalence, clinical pattern and outcome of patients with organophosphorus poisoning admitting a private hospital and in Al-Ggamhouria Teaching Hospital in Aden city in Yemen. Patients and Methods: It was a prospective study carried out in Al-Gamhouria Teaching Hospital and Private Hospital in Aden-Yemen over a period of two years, Between August 2019 to August 2021. It included 50 patients >16 years of age presented with organophosphates poisoning within 6 hours of OP exposure. Diagnosis was performed from the history taken from the patient, particular focus being given for sex, age, rural/urban background, clinical symptomatology, in addition to outcome. Results: During the study period, 50 patients were recruit-ed, mean age was 32±10 years, (62%) cases were females and (38%) were males, maximum of patients belonging to the age group of 21-40 years (70%), sweating was the most common clinical pattern at time of arrival, it was (92%) follow by Miosis (80%) excessive salivation (68%) bradycardia 50% muscle weakness (10%). Dead patients are (26%) of the subjects, while (74%) of patients were fully recovered. Conclusion: This study concluded that young female patients are the majority of patients with OP poisoning en-countered in hospitals, and sweating is the commonest pres-entation seen.