Abstract Liver diseases is a dynamic pathological condition which can be slowed down in its initial phases without proper clinical management of fibrosis Progressive liver damage may lead to cirrhosis and ultimately to liver failure or primary liver cancer which are irreversible conditions. In order to cure fibrotic damage to liver, its early stages should be the center of attention. Some supplements and complementary and alternative medicine (CAM) deserve specific mention, because of their already recognized natural way of healing and long lasting curative effects. Dietary supplements (DS) are extensive very consumed worldwide despite unproven efficacy. the true incidence of DS-induced liver injury (DSILI) is unknown, but is probably under diagnosed duo to the general belief of safety of these products, the present review is a systematic account of some herbs and supplements on both dual effects on liver (protective: Toxic), much additional work is still needed to explore mo-lecular pathways to discover potential applications of these alternative medicines.