Abstract Background: Lung cancer is one of most common malig-nancies worldwide. Pain is one of the most prevalent symptoms in patients diagnosed with lung cancer. Many therapeutic modalities proposed to provide pain relief in those patients. The aim of this study was to assess of the safety and effec-tiveness of Thermal Radio Frequency (TRF) of Dorsal root ganglion in treatment of chronic malignant thoracic pain. Aim of Study: Was to assess of the safety and effectiveness of Thermal Radio Frequency (TRF) of Dorsal root ganglion in treatment of chronic malignant thoracic pain. Patients and Methods: This prospective interventional study included 30 patients with lung cancer pain. The patients received TRF of Dorsal root ganglion corresponding to related pain dermatome at national cancer institute during the period from 1st of January 2015 to end of December 2018. Results: Visual analog scale, quality-of-life and quality of sleep scores were improved significant at Day 1, 1 week, 1m and 3m as compared to pre block. On assessment of post-operative complication four cases had dorsal back pain and two cases had neuritis. Conclusions: TRF leads to pain relief on long term but with minimal concerns in safety profile.