Abstract Background: Lung cancer is one of most common malig-nancies worldwide. Pain is one of the most prevalent symptoms in patients diagnosed with lung cancer. Many therapeutic modalities proposed to provide pain relief in those patients. Aim of Study: The aim of this study was to assess the safety and effectiveness chemical dorsal rhizotomy (phenol) in treatment of chronic malignant thoracic pain. Patients and Methods: This prospective interventional study included 30 patients with lung cancer pain. The patients received chemical phenol in dorsal rhizotomy corresponding to related pain dermatome at National Cancer Institute during the period from 1st of January 2015 to end of December 2018. Results: Visual analog scale, quality-of-life and quality of sleep scores were improved significantat Day 1, 1 week, 1m and 3m as compared to pre block. As regards complication, one case had dorsal back pain, and three cases had numbness. Conclusions: Chemical rhizotomyleads to pain relief on short and long term but has concerns in safety profile.