Abstract Background: Tumors of the thalamic origin represent about 2-5% of pediatric brain tumors. They are considered a challenging subset of brain tumors to both neurosurgeons and radiotherapists due to their critical anatomical position and the proximity of functionally significant structures especially in children. Aim of Study: Is to present the authors' experience in the management of 33 cases of pediatric thalamic brain tumors. Patients and Methods: Medical records of 33 pediatric patients with thalamic brain tumors admitted to CCHE during the period from July, 2007 till December, 2014 have been reviewed as regard surgical inter-ference, chemotherapy and radiation therapy in relevance to different histo-pathological subtypes, tumor size, patients' age and patients' presenting symptoms. Conclusion: Pediatric thalamic brain tumors are highly challenging tumors with significant level of morbidity and mortality that require integrated analysis of further studies to achieve better outcome.