Abstract Background: Glucose can be found in normal indivduals saliva; however, its secretion mechanism is still not clear. Increased glucose content in salivary secretion was reported in diabetic patients by many authors as the salivary glands filter the blood glucose. Aim of Study: The aim of this study was todetermine whether salivary glucose protein levels could be used as a noninvasive tool for diagnosis and glycemic control of type -1 diabetes in children. Material and Methods: 200 patients with type 1 DM, their ages range from 5 to 18 years old randomly assigned into 2 groups: Control and study groups. Group 1: 100 child with type 1DM according to American Diabetes Association 2015. Group 2: (Control group) 100 child apparently healthy with the same age and sex matched children. Fasting blood glucose, Glycosylated Hb (HbA1c), Salivary glucose and Salivary total proteins were measured. Results: There was a significant difference between the two groups in glucose level measured by glucose level con-centration in saliva which is higher in diabetic patients. Conclusion: The present study confirmed that salivary glucose protein levels could be used as a noninvasive and non expensive tool for diagnosis and glycemic control of type -1 diabetes in children.