Abstract Background: Breast cancer in women is a major public health problem throughout the world. It is the most common cancer among women both in developed and developing countries. Aim of Study: This study was undertaken to assess the diagnostic value of contrast enhanced mammography in detection of cancer breast.. Material and Methods: During the period from December 2015 to January 2017, 129 cases with 194 breast lesions in a prospective study presenting with various suspicious or equivocal lesions on mammography that underwent CEDM evaluation to test its diagnostic performance in the final diagnosis using the histopathology results as the gold standard of reference. The study includes 9 patients with past history of breast operations. Descriptive statisticswere used to analyze the data. Results: There were 129 females (the ages ranged from 25-88 years with a mean 50 years) with 194 lesions. Of these lesions 162 (83.5%) are malignant and 32 (16.5%) are benign. The study demonstrated contrast enhancement in 91.9% of the malignant and 41% of the benign lesions. Contrast en-hancement was observed in 136 malignant lesions. 22 (14.9%) lesions of malignant lesions took homogenous enhancement and 114 (77%) lesions took heterogeneous enhancement. In our study the margin of mass enhancing lesions showed ill-defined and speculated margins were significantly higher in malignant lesions. Conclusion: The use of dual energy contrast enhanced mammography technique can significantly improve the diag-nostic quality and cancer detection rate.